Abstracts of Scientific Studies and Research conducted on naive male rats to increase sexual motivation with Malaysian Ginseng (Eurycoma longifolia)

Several tests were conducted on Malaysian Ginseng as an aphrodisiac plant in laboratories of Malaysia. Below are some important results derived by using Malaysian Ginseng on different male rats.

Effects of Eurycoma longifolia (Malaysian Ginseng) on the initiation of sexual performance of inexperienced castrated male rats.

Date: 2001 Oct;
Code: 24(5):437-40
Conducted by: Ang HH and Cheang HS., Yusof AP.
School of Pharmaceutical Sciences,
University Science Malaysia , Minden , 11800,
Penang , Malaysia.

Study objective: Effects of Eurycoma longifolia Jack (Malaysian Ginseng) on the initiation of sexual performance of inexperienced castrated male rats.

We studied the effects of Eurycoma longifolia Jack, commonly known as Malaysian Ginseng in Malaysia , on the initiation of sexual performance and the weights of sexual accessories in inexperienced castrated male rats. The doses of 200, 400 and 800 mg/kg body weight, which were extracted from E. longifolia, were orally administered to the rats twice daily for 10 days prior to the tests and continued throughout the test period. Testosterone was used as a positive control after injecting 15 mg/kg daily subcutaneously for 32 days. Results showed that E. longifolia produced a dose-dependent increase in sexual performance of the treated animals, but the E. longifolia groups showed lower sexual performance in mounting, intromission and ejaculation than the testosterone group. Further results also showed that E. longifolia promoted the growth of both ventral prostate and seminal vesicles as compared with the control, but the growth of sexual accessories at 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia was less than that of testosterone treated group. The present study therefore gives further evidence of the folk use of E. longifolia as an aphrodisiac.

PMID: 10803359 [PubMed - indexed for MEDLINE]

Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia.

Date: 2002 July
Code: 19B-0.1-(36w)
Conducted By: Ang HH & Ngai TH.
School of Pharmaceutical Sciences,
University of Science , Malaysia ,
Minden , Singapore.

Study Objective: Aphrodisiac evaluation in non-copulator male rats after chronic administration of Eurycoma longifolia.

The aphrodisiac effect of Eurycoma longifolia (0.5 g/kg) was evaluated in non-copulator male rats using an electrical cage. Fractions of E. longifolia decreased the hesitation time of non-copulator male rats, throughout the investigation period. Furthermore, it possessed a transient increase in the percentage of the male rats responding to the right choice, more than 50% of the male rats scored "right choice" after 3 weeks post-treatment and the effect became more prominent after 8 weeks post-treatment (only 40-50% of the control male rats responded to the right choice) using the electrical copulation cage. Hence, this study lends further support to the use of the plant by indigenous populations as a traditional medicine for its aphrodisiac property.

PMID: 11564133 [PubMed - indexed for MEDLINE]

Sexual arousal in sexually sluggish old male rats after oral administration of Eurycoma longifolia.

Date: 2000 Jan
Code: Exp Anim;49(1):35-8
Conducted By: Ang HH, Lee KL, Kiyoshi M.
School of Pharmaceutical Sciences,
University Science Penang , Malaysia.

Study objectives: Sexual arousal in sexually sluggish old male rats after oral administration of Eurycoma longifolia.

Eurycoma longifolia commonly known as Malaysian Ginseng in Malaysia , has been used in Malaysia to increase male virility and sexual prowess. The objective of this study is to evaluate sexual arousal in sexually sluggish old male rats, 24 months old and retired breeders, receiving 200, 400, or 800 mg/kg of various fractions of E. longifolia, twice daily, for 10 days. Control rats received 3 ml/kg of normal saline. The aphrodisiac effect was monitored by the act of yawning and stretching because yawning, either alone or associated with stretching, is considered an ancestral vestige surviving throughout evolution that promotes sexual arousal. The results showed that 800 mg/kg of E. longifolia increased yawning by 50% and stretching by 16.7% in sexually sluggish old male rats, by 676-719% and 31-336%, respectively, in sexually active male rats, and by 22-44% and 75-100%, respectively, in middle aged, 9 months old and retired breeders. We conclude that the results of this study support the folk use of this plant as an aphrodisiac.

PMID: 15803965 [PubMed - indexed for MEDLINE]

Effects of Eurycoma longifolia on levator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats.

Date: 2001 Aug
Code: Exp Anim; 15(4):265-8
Conducted By: Fundam Clin Pharmacol Malaysia.

Research objective: Effects of Eurycoma longifolia on levator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats.

It has been reported that Eurycoma longifolia commonly known as Malaysian Ginseng has gained notoreity as a symbol of man’s ego and strength by the Malaysian men because it increases male virility and sexual prowess during sexual activities. As such, the effects of 200, 400 and 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia were studied on the levator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats after dosing them for 12 consecutive weeks. Results showed that 800 mg/kg of butanol, methanol, water and chloroform fractions of E. longifolia significantly increased (p<0.05) the levator ani muscle to 58.56+/-1.22, 58.23+/-0.31, 60.21 +/-0.86 and 62.35 +/-0.98 mg/100 g body weight, respectively, when compared with the control (untreated) in the uncastrated intact male rats and 49.23+/-0.82, 52.23+/-0.36, 50.21+/-0.66 and 52.35+/-0.58 mg/100 g body weight, respectively, when compared to control (untreated) in the testosterone-stimulated castrated intact male rats. Hence, the pro-androgenic effect as shown by this study further supported the traditional use of this plant as an aphrodisiac.

PMID: 11693547 [PubMed - indexed for MEDLINE]

Effect of Eurycoma longifolia on libido in middle-aged male rats.

Date: 2002 March
Code: USM-249-54. xNvL
Conducted By: Ang HH, Lee KL.University Science Malaysia , Minden , Penang , Malaysia
J Basic Clin Physiol Pharmacol

Study Objective: Effect of Eurycoma longifolia on libido in middle-aged male rats.

The effect of increasing doses of various fractions of Eurycoma longifolia extracts on libido was examined in middle-aged male rats. The results showed that a high dose (800 mg/kg) of all E. longifolia extracts significantly increased mount frequency (MF) (P < 0.05) over that of untreated controls, but had no effect on the frequency of intromission or ejaculation. Methanol, chloroform, water, and butanol fractions exhibited MF of 2.5 +/- 0.1, 2.6 +/- 0.3, 2.5 +/- 0.1 and 2.6 +/- 0.2, respectively, in adult, middle-aged male rats, and retired breeders versus 2.3 +/- 0.1 in untreated controls. This translated to a minor increase in MF of 8.7%, 13.0%, 8.7%, and 13.0% for these fractions, respectively, during the 20-minute observation period. The results of this study show that Eurycoma longifolia extracts can increase libido in middle-aged male rats.

Source: NATIONAL CENTRE FOR BIOTECHNOLOGY INFORMATION